NEUROPROTECTIVE EFFECT OF TIRON ON PARKINSON'S DISEASE
Shrook A. Mohamed, Dalia H. El-Kashef, Manar A. Nader
Department of Pharmacology and Toxicology, Faculty of Pharmacy,Mansoura University, Mansoura, 35516, Egypt
Parkinson's disease is a common, slowly progressive neurodegenerative disorder resulting from the degeneration of dopaminergic neurons in the substantia nigra. In the current study, we aim to investigate the neuroprotective effect of tiron against 1 -methyl- 4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced Parkinsonism. MPTP (30 mg/kg, ip) was injected in mice daily for 5 consecutive days. Mice were treated with tiron (140 mg/kg, ip) for 10 consecutive days, starting 5 days before MPTP injection. At the end of the experiment, behavioral tests were conducted to evaluate the neuroprotective effect of tiron. Tiron significantly inhibited the neurodegenerative deterioration induced by MPTP.
June 2020