HISTOPATHOLOGICAL STUDY OF THE EFFECT OF NANO L-CARNITINE ON SODUIM ARSENITE INDUCED HEPATOTOXICITY IN RAT
Nadia Noble-Daoud Aniss
Zoology Department –Faculty of Women for Arts, Science and Education.Ain Shams University, Cairo, Egypt
Agricultural and industrial developments in recent years have resulted in the excessive discharge of arsenic into the environment, making arsenic toxicity a major worldwide concern. Chronic exposure to arsenic over a period of time induces toxicity, primarily in the liver and gradually to all systems of the body. The main objective of this study was designated to investigate the effectiveness of Nano L-carnitine against arsenic induced hepatotoxcicity in male rats. Rats were divided into four groups of 10 rats each; Group (1): negative control, Group (2): arsinite group orally administered sodium arsenite (5mg/kg bw/day) Group (3): L-carnitine nano-form group orally administered 50 mg/kg, Group(4): L-carnitine nano-form treated group orally administered 50 mg/kg after recieving the arsenite . Rats were orally administered their respective doses every day for 30 days. Liver tissue samples were then extracted and were later analyzed for biochemical and histological alterations. Results showed that sodium arsenite raised the serum level of liver function markers such as Aspartate aminotransferase (AST), Alanine aminotransferase (ALT) and Alkaline phosphatase (ALP). However, Liver toxicity was not observed when rats were treated with Nano L-carnitine as the serum level of ALT, AST and ALP significantly decreased. Administration of Nano L-Carnitine ameliorates arsenic-induced oxidative damage, inflammation and caused signs of improvement in liver tissue architecture. The results obtained suggest that Nano L- carnitine is an enormous antioxidant treatment may prove beneficial and curative effect against arsenic induced hepatotoxicity.