IN VITRO BIOCOMPATIBILITY AND COMPARATIVE ANALYSIS OF DIFFERENT NANOSURFACE TITANIUM MATERIALS
Noha A. Alshuwayer
Department of Anatomy, College of Medicine, King Saud University Riyadh, Saudi Arabia
Cell-scaffold composites or nanomaterials have been utilized to improve tissue regeneration in the treatment of skeletal disorders and it leads to a successful outcome. The scaffolds provide structural stability, allow incorporation of biological or mechanical signals to enhance cell differentiation, and provide a 3D template on which the cells can proliferate and migrate, produce matrix, and form a functional tissue with a desired shape. Titanium is used widely in biomedical devices especially as dental and orthopedic implants (Sjöström, T. et al., 2009) due to its biocompatible, bioinert and mechanical properties (Yang W, Huang H. In Press 2009). The aim of this study was to test the biocompatibility of three different titanium nanosurfaces and run a comparative analysis between them. hMSC TERT (human bone marrow mesenchymal stem cells that have been immortalized with TERT gene) were used. hMSC TERT were viable on all three surfaces and the cell numbers increased with time. The growth of cells on the side of the titanium surface opposite to the seeding surface indicates the possibility that these cells have migrated around the edge of the surface.