EFFECT OF CORIANDRIUM SATIVUM SEEDS EXTRACT ON ARTERIAL CHANGES IN STREPTOZOTOCIN INDUCED DIABETES IN RATS: HISTOLOGICAL BIOCHEMICAL AND IMMUNOHISTOCHEMICAL STUDIES
Nesma M. Abd El-Karim, Fatma E. El-Safty, Hanaa Z. Nooh and Noha M. Issa
Department of Anatomy and Embryology, Faculty of Medicine, Menoufia University, Egypt
The macrovascular and microvascular complications were implicated in the morbidity and mortality of diabetic patients. The aim of this work is to study the effect of coriandrium sativum seeds extract on the aorta and femoral arteries in Streptozotocin-induced diabetic male albino rats: on histological, immunohistochemical & biochemical bases. Sixty (60) male albino rats were used and divided into group I (Control group), group II (Coriandrium Sativum group), group III (Diabetic group), group IV (Protected group) and group V (Treated group). Diabetes was induced by streptozotocin in the dose of 50mg/kg once (10mg/rat) by intraperitoneal injection, while the coriandrium sativum seeds extract was given in daily dose of 200 mg/kg for eight weeks orally by intragastric tube. The aorta and femoral arteries of the diabetic group showed various changes included increased thickness of tunica media together with disorganized elastic lamellae, formation of foam cells and proliferation of the smooth muscle cells in the tunica media. The coriandrium sativum protected the diabetic aorta and femoral arteries from the complications but cannot reverse these complications on the arteries of the treated group.