EFFECT OF AEROBIC EXERCISE ON THE OXIDATIVE STATUS AND SERUM LEVELS OF IL-6 AND IL-10 IN PATIENTS WITH SYSTEMIC LUPUS ERYTHROMATOSIS
1Ahmed Ali Abdelaziz, 2Shereen Rashad mohammed
1Department of rheumatology and rehabilitation, Faculty of Medicine, Al Azhar University
2Departments of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Fayoum University
Aim: Oxidative stress plays a role in systemic lupus erythromatosis (SLE), the effects of exercise on oxidative parameters and inflammatory cytokines in SLE are still to be elucidated. The aim of this study was to investigate the effects of aerobic exercise on serum malonedialdehyde (MDA), serum total antioxidant capacity (TAC), IL-6 and IL-10 in SLE patients. Methods: 21 patients with SLE and 21 age and sex matched healthy volunteers participated in this study. Aerobic exercise consists of an initial warming period about 5 minutes followed by 30 minutes running on a treadmill then cooling down period of about 5 minutes, this program was applied for 8 weeks. Blood samples were obtained before applying the program and after the 8 weeks. malondialdehyde (MDA),total antioxidant capacity (TAC), IL-6 and IL-10 were measured. Results: Serum MDA levels decreased significantly with exercise in both groups (p<0.05). TAC levels increased significantly after the exercise program in patients group only (p<0.05). The levels of IL-6 decreased significantly in patients group only after exercise while IL-10 was elevated but this elevation is insignificant in both groups Conclusion: Submaximal exercise had improved the oxidative status in patients with SLE; therefore, we should focus on oxidative stress in the treatment for SLE with the main objective of reducing oxidative load. So we suggest that regular exercise at submaximal intensity should be considered in SLE rehabilitation program.