OXIDATIVE STRESS AND HISTOPATHOLOGICAL CHANGES IN CATTLE AFFECTED WITH FASCIOLIASIS AND CYSTICERCOSIS Mariam. A. Atteya1, Ahmed A. Wahba2, Mahi. A. Ghobashy3, Amina. A. Dessouky4 1 Department of Parasitology, Animal Health Research Institute, Ismailia 2 Department of Parasitology, Animal Health Research Institute, Dokki, Giza 3 Department of Zoology, Faculty of Science, Suez Canal University. 4 Department of Pathology, Faculty of Veterinary Medicine, Suez Canal University. Corresponding Author: email@example.com
Oxidative stress is a general mechanism whereby free radicals induce oxidative damages and reduce the antioxidant defenses of the biological systems. The highly reactive oxygen species represent a powerful effector mechanism against parasites. The present study aimed to determinate the activities of the main defense enzymatic and non-enzymatic antioxidants in cattle tissues and estimation of the pathological changes associated with fascioliasis and cysticercosis. There is a statistically significant decrease in antioxidant (SOD, CAT, GSH, GST) in cattle tissues infected with fascioliasis and cysticercosis (23.32, 0.20, 6.71, 32.05), (42.9, 0.28, 3.61, 22.78) respectively. On the other hand, there is a statistically significant increask3e in MDA levels as a biomarker of lipid peroxidation (16.55, 11.21) in contrast with control samples. The common histopathological changes in tissue of infected cattle with Fasciola sp. and Cysticercus bovis are represented by lymphocytic infiltration, necrosis and fatty changes. The results in the present study support the significance of antioxidant process in host defense mechanism during parasitic infection and clarify the pathological damage associated with oxidative stress.