SERO-EPIDEMIOLOGICAL PROFILE OF TOXOPLASMA INFECTED PREGNANT WOMEN IN RELATION TO REPEATED ABORTION AT KASR AL-AINY OBSTETRICS AND GYNAECOLOGY OUTPATIENT CLINICS IN CAIRO, EGYPT
Mona Said El-Sherbini1, Amany A Abd El-Aal1, Walid Sayed El-Sherbiny2, Samar Sayed Attia1, Mohamed Zaki Badr3, and Inas Abdel Aziz1
Departments of Medical Parasitology1and Obestetric & Gynaecology2, Faculty of Medicine, Cairo University, Cairo, Egypt Department of Molecular Biology3, Medical Research Center, Faculty of Medicine, Ain Shams University, Giza, Egypt.
The work was designed to search for some causative and risk factors in 61 pregnant women serologically positive for Toxoplasma antibodies who had history of recurrent abortion with absolutely no children (group1) or with successful outcomes, more than 2 children (group 3) compared with multiparous (group 2) at Kasr Al-Ainy Obstetrics and Gynaecology outpatient Clinics in Cairo from the period of September 2013 till April 2014. In the present study, the combined IgG and IgM seropositivity against Toxoplasma reported statistically significant high rate (74%) in group1 compared to the other 2 groups, reflecting the likely assembly between the apparent reactivation of a latent Toxoplasma infection in occurrence of repeated abortion in such chronically infected group.The socio-demographic profile illustrated the importance of animal contact as a mode of Toxoplasma transmission in our study group which proved to be statistically significantly higher in group1. Collectively the variation between the three study groups and their close contact with animals was also found to be significant (P ≤ 0.0001). While, age of the studied groups and other risk factors like residence, educational level and previous treatment to toxoplasmosis were all investigated, but no clear statistical significance was determined. Findings of this study gives support to a Toxoplasma screening programme and health education exclusively in seronegative women during child bearing age in order to prevent the frequent occurrence of this zoonosis.
December 2015