EJMS

Abstract

Introduction: Amiodarone is considered one of the most common drugs used in the treatment of heart diseases despite of its numerous complications especially pulmonary toxicity. Aim of work: the aim of the present study is to investigate the possible protective role of Inositol Hexaphosphate (IP6) on pulmonary toxicity induced by Amiodarone in adult male albino rats. Material & Methods: the present study was carried out on forty adult male Albino rats divided into 4 equal groups: group I (control group), group II (IP6 treated group) received IP6 three times per week for four weeks at a total dose of 40 mg/kg by gavage, group IIІ (Amiodarone treated group) received Amiodarone in a daily dose of 30 mg/kg body weight for four weeks by oral gavage and group VI (IP6 and Amiodarone treated group) received IP6 three times per week for four weeks at a total dose of 40 mg/kg by gavage and in addition received Amiodarone in a daily dose of 30 mg/kg body weight for four weeks by oral gavage. The animals were sacrificed at the end of the experiment and the lungs were excised and prepared for histological and Immunohistochemical studies. Results: Administration of Amiodarone produced changes in the lung architecture in the form of collapsed alveoli, thickening of interalveolar septae, cellular infilteration, collagen deposition and significant (P<0.05) increase in number of macrophages as revealed by morphometric study. Intrabronchial cellular debris and vascular congestion were found. Concomitant administration of IP6 with Amiodarone demonstrated a considerable degree of preservation of alveolar architecture, scanty collagen deposition with few numbers of macrophages. Conclusion: From the present study it could be concluded that administration of Amiodarone in rats can induces severe lung damage. Concomitant administration of IP6 effectively protected the pulmonary tissue from the toxicity induced by Amiodarone in adult male albino rats.