RUTIN ATTENUATES HYPERLIPIDEMIA AND CARDIAC OXIDATIVE STRESS IN DIABETIC RATS
Ayman M. Mahmouda* & Ayman S. Solimanb
aPhysiology Division, Zoology Department, Faculty of Science, bPhysiology Department, Faculty of Medicine, Beni-Suef University, Egypt.
The current study aimed to investigate the anti-hyperlipidemic and cardioprotective effects of rutin in streptozotocin (STZ)-induced diabetic rats. Diabetes was induced by intraperitoneal injection of 45 mg/kg body weight streptozotocin to overnight fasted rats. Oral administration of 50 mg/kg body weight ruin for 30 days significantly reduced glucose levels in diabetic rats. Determination of serum insulin levels revealed the insulin stimulating action of rutin. Compared to diabetic control rats, rutin-treated diabetic rats had significantly reduced serum total cholesterol, triglycerides, LDL-cholesterol and vLDL-cholesterol. In addition, rutin treatment significantly alleviated the altered serum cardiac enzymes and cardiac lipid peroxidation levels. Further, rutin supplementation markedly ameliorated cardiac enzymatic and non-enzymatic antioxidant defenses. In conclusion, the current study suggests that rutin might protect heart against hyperglycemia-associated oxidative stress via reducing lipid peroxidation, retaining activities of the antioxidant enzymes and sparing GSH levels. In addition, the cardioprotective effects of rutin might be attributed to its anti-hyperlipidemic as well as antiatherogenic effects.
June 2013