EJMS

Abstract

Objectives: To estimate serum concentration of resistin in pediatric patient with chronic renal failure (CRF) on conservative treatment and on hemodialysis. Patients & Methods: The study included 30 children; 19 males and 11 females with mean age of 15±3.9 years and 20 age and sex matched healthy children. Patients and control were categorized according to calculation of glomerular filtration rate (GFR) by Modification of Diet in Renal Disease into CRF group and end-stage renal disease (ESRD) group. All patients and controls underwent determination of body mass index (BMI) parameters and gave blood samples for determination of complete blood count (CBC) and estimation of serum high-sensitivity C-reactive protein (hs-CRP) and serum resistin. Results: GFR, Hemoglobin concentration and platelet count and serum albumin levels were significantly decreased in patients compared to controls with significantly lower GFR in ESRD group compared to CRF group. White blood cell (WBC) count, serum hs-CRP and potassium levels were significantly higher in patients compared to controls. Serum levels of resistin were significantly increased in both patient groups compared to control group with significantly higher serum resistin levels in ESRD group compared to CRF group. Moreover, serum resistin showed negative significant correlation with GFR in all studied groups, but showed positive significant correlation with serum levels of hs-CRP and WBC count in patients groups. Conclusion: Elevated serum resistin level in pediatric patients with CRF and/or ESRD and on hemodialysis was negatively correlated with GFR and positively correlated with hs-CRP serum level and WBC count; so it may underlay the progression of renal disease and could be used to assess the prognosis of kidney affection. However, wider scale studies are recommended for evaluation of its prognostic applicability and to determine cutoff points for evaluation of renal condition.