EFFECT OF SELENIUM ON SOME PHYSIOLOGICAL PARAMETERS IN RATS TREATED WITH CADMIUM
Abd–El Hamid. A. Abd–EL Hamid
Department of Animal Physiology, Animal Production, Faculty of Agriculture, Al – Azhar University, Cairo, Egypt
This study was designed to evaluate the protective effect of selenium against cadmium toxicity. A total of 24 adult male rats with body weight ranged from 122 – 145 g. Were distributed into four groups, 6 rats each, assigned into four treatment groups: (1) control, (2) Cadmium 10 mg/kg, (3) selenium 0.5mg/kg BW(4) selenium 0.5 mg/kg BW Plus cadmium 10 mg/kg BW . Administered orally their respective doses every other days for 8 weeks blood samples were collected at 4 and 8 weeks from the start of the experiment. Results showed that oral administration of cadmium significantly increased plasma ALT, AST: alkaline phospatase, urea, createnin, cholesterol, triglycerides and glucose and significantly decreased plasma total protein and albumin ural administration of selenium in combination with cadmium alleviated all of its toxic effects which were recognized from retaining the levels of the studied plasma parameters either near the normal levels of the control group. Conclusion: Selenium has beneficial effects and ability to prevent the toxic effects of cadmium.
June 2012