HISTOPATHOLOGICAL CHANGES IN SOME ORGANS EXPOSED TO MALATHION AND DIMETHOATE INSECTICIDES AND ITS CYTOGENETIC EFFECTS ON GUINEA PIGS, CAVIA PORCELLUS.
Mohamed A. Salama
Department of Zoology, Faculty of Science, Zagazig University
Evaluation of toxic effects of insecticides used for domestic and agricultural applications is of a major concern to public health, so this work has been done. Hypertrophy and deterioration of RBCs, chromosomal aberrations of bone marrow cells including stickiness, deletion, and chromatid gap as well as chromosome annual ring were the most recorded observations. Obvious renal tubular laceration, intertubular hemorrhage, glomerular shrinkage and widening of Bowman’s space were recorded. Furthermore, hepatic lesions showed vaculation, swelling and degeneration of hepatocytes with various degrees of pyknosis and necrosis. The spleen showed amorphous acidophilic deposits, congested blood vessels and lymphocytic infiltration. Exposures to these insecticides (Malathion and Dimethoate) cause hazardous effects on the organs, their structures and their chromosomal pattern. So, avoidance of direct exposure to these toxic components must be taken in consideration during application of these materials.
June 2012