SCHISTOSOMIASIS INFESTATION MIGHT AFFECT THE LEVEL OF SERUM TUMOR MARKERS IN HEPATITIS B VIRAL INFECTED PATIENTS COMPLICATED WITH HEPATOCELLULAR CARCINOMA
Hanaa A. Mansoura, Maha G. Solimanb, Wedad A. Hassanaa and Salwa M. Ahmedc
aDepartment of Pharmacology, National Organization of Drug Control and Research (NODCAR), Giza, Egypt bDepartment of Zoology, Faculty of Science, Al-Azhar University For Girls, Cairo, Egypt
cClinical Pathology, Central Laboratory of Egypt Air Lines Hospital, Cairo, Egypt
Hepatitis B virus (HBV) infection is a worldwide liver disease and nearly 25% of chronic HBV infections terminate in hepatocellular carcinoma (HCC). The serum level of tumor markers namely Alpha-fetoprotein, Des-gamma-carboxyprothrombin (DCP) PEVIKA II, Carcinoembryonic antigen CEA, Carbohydrate antigen 19-9 CA 19-9 and gamma-glutamyltransferase GGT were estimated in hepatitis B viral infected patients complicated with hepatocellular carcinoma, being compared with those found in the serum of patients co-infected with Schistosoma mansoni. In addition, the study in sighted the level of liver enzymes, liver produced proteins namely, total proteins, albumin and globulin, also bleeding tendency parameters were evaluated. The results of the study demonstrated that Schistosoma mansoni infection significantly affected the levels of Alpha-fetoprotein AFP and Carbohydrate antigen 19-9 CA 19-9. Also, the levels of direct bilirubin and PT -INR (%) were significantly changed.
December 2012