MICROPARTICLES IN PATIENTS WITH BREAST CANCER; POSSIBLE ROLE IN HYPERCOAGULABLE STATE
Khaled S. Osman*, Mohamed E. Abd Al-Fattah** and Shaimaa M. Mady**
Departments of Clinical Pathology* and Internal Medicine**, Faculty of Medicine, Minia University
The study was aimed to determine the level of circulating microparticles in patients with breast cancer and to assess if they have a potential role in the hypercoagulable state observed in such patients. The study was carried in El-Minia University hospital and included 35 patients with breast cancer (group I) compared to 10 healthy subjects of matched age (group II). After full history taking and clinical examination, complete blood picture, liver function tests, renal function tests, measuring Thrombin-antithrombin complex and microparticles were performed. There was significantly higher statistical difference in breast cancer patients than control group regarding Thrombin-antithrombin complex (p = 0.047), also, highly significant statistical difference between group I and group II when comparing microparticles in both groups (p = 0.001). We concluded that microparticles play a role in the pathogenesis of thrombotic events, may correlate with tumor size and predict thrombosis in patients with breast cancer.
December 2011