EFFECT OF NO MODULATOR ON EXPERIMENTALLY INDUCED VASCULAR CALCIFICATION
Ahmed.Amera, Ahmed R. El-Sheakhb, Mohamed F Hamedc, Shehatou GSa,b, H El-Kashefa,b, Manar A Naderb
aDepartment of Pharmacology and Biochemistry, Faculty of Pharmacy, Delta University for Science & Technology, International Coastal Road, Gamasa City, Mansoura
bDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, University of Mansoura, Mansoura.
cDepartment of Pathology, Faculty of Veterinary Medicine, University of Mansoura, Mansoura.
This study was designed to investigate the effect of agmatine sulfate (AGM, CAS2482-00-0) in Vitamin D3 plus nicotine (VDN)- induced vascular calcification (VC) in rats. VDN were administered to produce VC in Wistar rats with or without AGM for 4 weeks. Serum concentration of calcium and serum alkaline phosphatase (ALP) activity was detected. Aortic concentration of malondialdehyde (MDA) was determined. AGM treatment markedly reduced VDN-induced elevation in MDA content in aorta and serum alkaline phosphatase activity. However, AGM significantly increased VDN-induced reduction in serum calcium level. Therefore, agmatine successfully attenuated VC induced by VDN treatment and its antioxidant activity may contributed to this effect .
June 2019