IMPACT OF HUMAN FASCIOLIASIS ON OXIDATIVE STRESS
Atef M. Aly El Shazly*, Mai A.Hegazi, Mona A. Abd Raboo, Omayma H.M.Sarhan**and Eman N. Hafez.***
Departments of Parasitology and Biochemistry**, Faculties of Medicine, Mansoura University, Mansoura*, Al Azhar University, Cairo and National Centre for Radiation, Research and Technology***.
The influence of Fasciola infection on the antioxidant defense potential of the human host was assessed. Fifty four cases of proven human fascioliasis with different intensities of infection and fifteen healthy parasite free persons were enrolled in the present work. Biochemical assessment of the antioxidant defense status included measuring of enzymatic activities of Superoxide dismutase, Catalase and total Glutathione Peroxidase and estimation of vitamin E concentration as a non-enzymatic antioxidant in blood. Results exhibited significant reduced levels of activities of Superoxide dismutase, Catalase, total Glutathione Peroxidase and vitamin E in fascioliasis cases with different intensities of infection in comparison to control. Reduced antioxidant abilities at the course of fascioliasis and enhanced generation of reactive oxygen species are synergetic to super add the destructive effect of fascioliasis.
December 2011