EJMS

Abstract

This study was designed to investigate the effect of acute environmental stressors on immune system. The direct continuous light, heat exposure and noise stress might affect the susceptibility or course cytokines. Among these cytokines, tumor necrosis factor-alpha (TNF-α), interleukin (IL)-6 and transforming growth factor (TGF-1β) were detected by ELISA technique. In the current study eighty male albino rats were used. The rats were divided into 4 groups. The 1st group was control without stress, and the 2nd group was exposed to noise stress at 100 dB/4h / 20 days. The 3rd group was exposed to heat stress in heating chamber at 42°C/45min /20 days. The 4th group was exposed to direct light stress at 24h/20 days. The results of the current study revealed that the levels of IL-6 was increased significantly in the group exposed to noise stress with percent change 80.7%. On the other, hand IL-6 revealed significant decreases in the groups exposed to heat stress and direct light stress. Also the data revealed that the TNF-α level was increased significantly in groups exposed to noise, heat and direct light stressors with percent change 75.1%, 89.1% and 91.6% respectively as compared to control group. Also the data revealed that the TGF-1β recorded significant increase in the groups exposed to noise, heat and direct light stressors with percent change 48.6%, 63.6% and 54.5% respectively in comparison to control group. The total WBCs count recorded a significant decrease in all groups exposed to the direct continuous light, heat and noise stressors as compared to control without stress.