CORRELATION OF OVARIAN VOLUME AND INCREASED INSULIN RESISTANCE IN PATIENTS WITH POLYCYSTIC OVARY SYNDROME
Ahmed Bakry1, Mariam Dawoud1, Ayman Aly Hamed Elsallamy2, Sayed Korany3, Nancy Ahmed4, Mohamed El Hodiby2, Tarek El Husseiny1
1Department of Obstetrics and Gynecology, Faculty of Medicine, Cairo University
2Department of Obstetrics and Gynecology, Faculty of Medicine, Misr University for Science and Technology, 6th October City, Giza
3Department of Obstetrics and Gynaecology Faculty of Medicine, Ain Shams University. 4Department of Obstetrics and Gynaecology Faculty of Medicine, Beni Suef University.
Background: Polycystic ovary syndrome (PCOS) is the commonest endocrine abnormality in women of reproductive age. The prevalence of PCOS is variable between different populations and ranged from 6% to 13%. It is a syndrome of ovarian dysfunction (oligo-ovulation or anovulation) along with the cardinal features of hyperandrogenism or hyperandrogenemia and Polycystic Ovary morphology (PCO) by ultrasound. The primary metabolic abnormality of PCOS is insulin resistance and compensatory hyperinsulinemia; however, the relationship between ovarian volume and insulin resistance in patients with PCOS has not been elucidated. Aim of work: To establish a correlation between the ovarian volume (OV) and antral follicular count (AFC) with Insulin resistance (IR) in patients with polycystic ovary syndrome (PCOS). Methods: In this study, we recruited 100 Egyptian females diagnosed as PCOS by Rotterdam’s criteria from February 2019 to July 2019. Patients aged 20-40 years were included in the study. Patients with known chronic illness or underwent ovarian surgery were excluded from the study. We assessed patients’ Age, BMI, FSH, LH, E2, AMH, fasting blood glucose, 2 hours postprandial glucose and fasting insulin as independent variables. Patients were monitored by transvaginal ultrasound examination to evaluate the antral follicular count and ovarian volume. Results: Strong positive correlation between ovarian volume (both ovaries >10cm3) and insulin resistance (P-value 0.006) in women of reproductive age with PCOS, while the correlation between AFC (>25) and insulin resistance showed to be statistically insignificant (P-value 0.753). Also, there is no correlation in patients meeting (OV in both ovaries >10 cm3 together with AFC>25) with insulin resistance (P-value 0.073). Conclusion: There is a strong positive correlation between ovarian volume and insulin resistance in women of reproductive age with PCOS.
June 2019