IVABRADINE PREVENTS CISPLATIN–INDUCED TESTICULAR AND EPIDIDYMAL INJURIES THROUGH INHIBITION OF OXIDATIVE STRESS
Sarah M. Al-Zaidi, Ahmed R. El-Sheakh1,2, Mirhan Nazmy Makled1
1Department of Pharmacolog and Toxicology Faculty of Pharmacy, Mansoura University
2Department of Pharmacolog and Toxicology Faculty of Pharmacy, Mansoura National University
Cisplatin is a chemotherapeutic agent whose therapeutic use is largely limited by associated organ toxicity including, testicular toxicity. Cisplatin-induced testicular and epididymal damage reported to be mediated through induction of oxidative stress. Ivabradine (Iva) has been reported to inhibit oxidative stress in different setting. This led us to hypothesize that Ivabradine (Iva) could abrogate cisplatin-induced testicular injury via it is antioxidant effect Histopathological examination demonstrates degenerative changes of spermatid epithelium and normal sertoli cells in testicular tissues of Iva group and normal duct with normal lining epithelium, but lumen is not completely blocked with spermatozoa in epididymal tissues .This was consistent with the restoration of a balanced oxidative status in testicular tissues, as indicated by an increase in total antioxidant capacity, glutathione, and superoxide dismutase activity, and a decrease in malondialdehyde content (<p 0.05 vs. Cisplatin). These findings suggest that Iva could be a promising treatment for preventing cisplatin-induced testicular and epididymal toxicity through it is an antioxidant effects.