EJMS

Abstract

Aim: Diabetes is a long-term metabolic disorder characterized by chronic inflammation and persistent high blood sugar levels. This condition triggers the excessive production of reactive oxygen species (ROS) and pro-inflammatory cytokines, which play a crucial role in the development of diabetic nephropathy. The primary focus of this study is to examine the effects of jojoba oil in preventing the advancement of DN. Methods: Diabetic nephropathy was established by single(i.p) injection of streptozotocin. After 2 months of treatment with jojoba oil (0.6 g/kg) , kidney function test and oxidative evaluation were conducted . Interleukin-6 levels were assessed by using ELISA technique. Histopathological examination of renal tissues was performed via staining with hematoxylin & eosin stain. Key findings: The administration of jojoba oil to DN rats resulted in decreased blood glucose, serum creatinine, blood urea nitrogen(BUN), and protein levels in urine. Additionally, the rats that received treatment displayed a significant decline in malonaldehyde content in their kidneys and a rise in glutathione levels in renal tissue. Moreover, there was a significant decrease in kidney levels of interleukin-6 observed in the treated group. Lastly, it can be noted that jojoba oil has a significant role in reducing histological abnormalities that are induced by nephropathy. Significance: jojoba oil, a natural compound, has been found to possess antioxidant, anti-inflammatory, and anti-diabetic effects. As a result, jojoba oil could play a protective role in slowing down the advancement of diabetic nephropathy. Abbreviations: DN: diabetic nephropathy, , ELISA: Enzyme-linked immunosorbent assay; H&E: Hematoxylin & Eosin, MDA: Malondialdehyde, GSH: Glutathione, GFR : glomerular filtration rate , ESKD : end-stage kidney disease , GBM : glomerular basement membrane , Col4: type IV collagen , AGEs : advanced glycation end products , IL-6 : Interleukin-6,STZ: streptozotocin.