THE DUAL ROLE OF VITAMIN D IN OSTEOPOROSIS TREATMENT
Ahmed Talaat Abd Elaziz1, Hanaa Mohamed Elzahed2
1Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Cairo University,
2Forensic Medicine Department, Faculty of Medicine, Cairo University
Background: Osteoporosis is state demarcated by decrease in bone mass and increase in bone fragility, in addition to increase the risk of fractures. Osteoporosis can occur as a result of interaction between metabolic, endocrine, and mechanical factors. proinflammatory cytokines are involved in the regulation of osteoblasts and osteoclasts. Nowadays, there is an evidence that vitamin D3 deficiency is a precipitating factor in the chronic diseases development. Vitamin D plays an important role in normal calcium and bone homeostasis though stimulation of osteogenesis and inhibition of pro-inflammatory cytokines production. Methods: fifty rats were included in the experiment and were divided in to five groups of ten rats in each group as the following: group1: control group; group2: induced osteoporosis group; group3: induced osteoporosis received vitamin D for one month; group4: induced osteoporosis received vitamin D for two months; group 5: induced osteoporosis received vitamin D for three months. Serum samples were collected for estimation of inflammatory cytokines (IL1, IL 6, and TNF) and inflammatory cytokines (IL10 and IL13) and bone marker (RANKL, osteocalcin, and ALP) by ELISA technique. Results: vitamin D treatment suppress the inflammation and improve the immune system in addition to stimulation of new bone formation through inhibition of RANKL and stimulation of osteocalcin and ALP. Conclusion: vitamin D can be considered an effective therapeutic agent for osteoporosis.
June 2018