EFFECT OF LOW BLOOD HEMOGLOBIN LEVEL ON ELECTROPHYSIOLOGICAL AND CLINICAL OUTCOME IN DIABETIC POLYNEUROPATHY PATIENTS
Khaled Eltoukhy, Hossam Egila
Neurology Department, Faculty of Medicine, Mansoura University, Egypt
Background: Hyperglycemia is one among some other conditions causing micro vascular complications in Diabetic polyneuropathy (DPN), Anemia is also one of the causes, and it can influence both severity and outcome in those patients. This fact created an area of attraction to study the predictive role of Anemia in DPN. Objectives: his study correlates Anemia (low HB level) to the severity and outcome of diabetic patients suffering diabetic neuropathy. Methods: This study was done cross sectionally on two hundred patients suffering type 2 diabetes (one hundred patients were suffering DPN and the other hundred were not). The two hundred patients were tested for anemia. Those 100 patients suffering DPN were assessed clinically and Electrophysiologically by Nerve conduction studies (Motor and sensory), and the outcome of their disease was determined by neuropathy disability score. Results: There was a statistically significant difference regarding Hb level between patients suffering DPN and those not suffering in both males and females and also among anemic and nonanemic subgroups. Anemic subgroup had a statistically significant more disability than non-anemic subgroup. Tibial and Peroneal nerves motor and sensory nerve conduction studies showed statistically significant more prolonged latency, more decreased amplitude and velocity in the anemic subgroup versus the non-anemic subgroup. Conclusion: Hemoglobin level is a potent factor influencing DPN and it can be used as a predictor for its severity and outcome.